5MECPG EPIGENETIC MARKS NEIGHBORING A PRIMATE-CONSERVED CORE PROMOTER SHORT TANDEM REPEAT INDICATE X-CHROMOSOME INACTIVATION.

5meCpG epigenetic marks neighboring a primate-conserved core promoter short tandem repeat indicate X-chromosome inactivation.

X-chromosome inactivation (XCI) is the epigenetic transcriptional silencing of an X-chromosome during the early stages of embryonic development in female eutherian mammals.XCI assures monoallelic expression in each cell and compensation for dosage-sensitive X-linked genes between females (XX) and males (XY).DNA methylation at the carbon-5 position

read more

Pathogenetic role of the pain threshold Hypothetical therapeutic perspectives based on the use of drugs to elevate it

The pain threshold determines the extent of pain perception, and in some cases, its manifestation.Therefore, it is important in certain situations to Clamps increase the pain threshold.Measuring the pain threshold is challenging due to its approximate nature.The threshold depends on the number and function of Nav1.7 sodium channels and nerve growth

read more

The meaning of structural breaks for risk management: new evidence, mechanisms, and innovative views for the post-COVID-19 era

This paper quantitatively reveals the meaning of structural breaks for risk management by analyzing US and major European banking sector stocks.Applying newly extended Glosten-Jagannathan-Runkle generalized autoregressive conditional heteroscedasticity models, we supply the following new evidence.First, we find that incorporating structural breaks

read more

Advances in Wishart-Type Modelling of Channel Capacity

This paper paves the way when the assumption of normality is challenged within the wireless communications systems arena.Innovative results pertaining to the distributions of quadratic forms and their associated eigenvalue density functions for the complex elliptical Pentair Prowler Parts family are derived, which includes an original Rayleigh-type

read more